New Delhi: A special court on Monday sent former Finance minister P Chidambaram to four more days of CBI custody till August 30 in the INX Media case after the probe agency said “certain evidence” had emerged and that the Congress leader’s confrontation with a co-accused during interrogation was incomplete.The Central Bureau of Investigation(CBI) had sought extension of Chidambaram’s custody by five days to confront him with certain e-mails and to unearth larger conspiracy in the corruption case in the INX Media scam. Also Read – India gets first tranche of Swiss bank a/c detailsSpecial Judge Ajay Kumar Kuhar said the CBI demand was “justified” for further interrogating the Congress leader. Chidambaram, 73, was produced in the special court on the expiry of his four-day CBI custody which was granted to the agency on August 22, a day after he was arrested amid high drama from his Delhi residence. His counsel Kapil Sibal opposed the CBI plea during the hearing, saying the agency was not disclosing “full facts” of the case to the court. “The CBI’s investigation is clouded. This method of seeking remand behind curtains is not fair.” Also Read – Tourists to be allowed in J&K from ThursdayThe Supreme Court, meanwhile, extended till Tuesday the protection from arrest given to Chidambaram in the separate money laundering case lodged by the Enforcement Directorate(ED). The ED’s affidavit claimed that the former Finance Minister was in touch with people running shell companies abroad allegedly connected to him. But the Supreme Court’s protection to Chidambaram from ED did not amount to much as a Special CBI court here extended his CBI custody till August 30, allowing the latter to question him in custody for four more days. Appearing for the probe agency at the trial court later in the day, Solicitor-General Tushar Mehta argued that five more days of Chidambaram’s custody is required as the investigators need to confront him with other co-accused in the case. He added that the senior Congress leader was confronted with one co-accused on Monday. The CBI sources here said that Chidambaram was confronted with Sindhushree Khullar, the former NITI Aayog CEO. They added that he was also confronted with some email exchanges between Karti Chidambaram — also accused in the case — and another co-accused.
FREDERICTON – Flood-weary residents of New Brunswick’s Darlings Island are praising the efforts of a man dubbed “Uber Rob.”The only road to the small island has been submerged by the flood waters of the Kennebecasis River, forcing residents to make the trip to and from their homes by boat.While many people are using canoes and kayaks, Rob Dekany has been ferrying seven passengers at a time to and from the island since Monday and refuses to accept any payment.Many residents say he’s been their saviour, but Dekany says it just makes him happy to help.Heavy rain overnight helped feed flood waters throughout the province.The Trans-Canada Highway between Fredericton and Moncton has been closed to traffic because the four-lane highway has been flooded.
OTTAWA – Canada’s spy agency ended its investigation of right-wing extremism 10 months before a gunman killed six worshippers at a Quebec City mosque, a new report reveals.The federal spy watchdog says the Canadian Security Intelligence Service reopened the probe following the shooting.Alexandre Bissonnette, 28, pleaded guilty in March to six charges of first-degree murder and six of attempted murder in the Quebec mosque attack.The Security Intelligence Review Committee’s annual report, tabled in Parliament on Wednesday, says CSIS characterizes right-wing extremism in Canada as a complex range of groups and individuals — from white nationalists and anti-gay forces to anti-Semites and people opposed to immigration.An internal CSIS review found the most of these activities amounted to — or were close to — lawful protest, advocacy or dissent, not threats to national security. As a result, the spy service concluded “the current threat environment no longer met the threshold of a CSIS investigation.”CSIS also determined the threat was being appropriately addressed by police, and questioned the additional value of its own efforts.The review committee looked at CSIS’s activities since 2012 with respect to right-wing extremism investigations as well as the impact, if any, of the January 2017 killings on the spy service’s work.Following the mosque attack, the review committee has seen CSIS “engage more extensively and frequently” with the RCMP and other law enforcement partners to better understand the threat posed by right-wing extremism that would fall under CSIS’s mandate, the report says.“According to CSIS, violence is usually infrequent, unplanned, and opportunistic, and is carried out by individuals rather than groups.”Overall, the committee found that CSIS activities conducted during the period of Jan. 1, 2012, to June 30, 2017, complied with the CSIS Act and ministerial direction on intelligence priorities.CSIS activities were also consistent with the authorities and limitations set out in its targeting policy, the report says.Partnerships with police and law enforcement agencies in Quebec and elsewhere — along with other, unspecified investigative tools at CSIS’s disposal — played an important part in the investigation, the report adds.“Besides helping to maintain awareness, these tools were valuable in investigating right-wing extremism activities that may present a threat to the security of Canada, including, for example, hate crimes against Muslims.”Conscious of recent events, including white-supremacist violence in Charlottesville, Va., the review committee plans to revisit the issue “in the medium term.”— Follow @JimBronskill on Twitter
Rabat – Dutch-Moroccan Abdelaziz Aouragh has denied rumors that his Al Asira shop specializing in sensual oils is planning to open a “halal sex shop” that sells “Islamically-approved” sex products in the cradle of Islam, Mecca.International media have been reporting extensively on the matter saying that Abdelaziz Aouragh, a second-generation Amsterdammer of Moroccan descent, is expected to open what they dubbed as a “halal sex shop” in Mecca, one of the holiest sites for Muslims and the center of the Islamic faith.“There have been media reports of a “halal sex shop” to be opened in Mecca. This is a false report. We are not a sex shop in anyway let alone a halal sex shop, whatever that may be,” said Abdelaziz Aouragh in an official statement. The Moroccan was also reported that he would be allying with Germany’s largest erotic retailer, Beate Uhse, for the selling of Islam-appropriate sex toys in his mecca store.“We have the ambition to open a concept store. That’s something totally different. Unfortunately media worldwide have taken that article as their reference, without taking the time and effort to just simply ask El Asira,” the CEO and Founder of Al Asira added.While he said that his Amsterdam-based shop is specializing in selling products that increase feelings of sensuality and improve the atmosphere between married couples, he denied selling blow-up dolls or vibrators, adding that El Asira provides products such as oils, creams and lotions which do not violate Islamic rules.
Toronto has topped the list of major global cities most at risk of a housing bubble with Vancouver ranking fourth, according to a new report by UBS Group AB.It’s the first time Toronto has cracked the annual rankings compiled for the UBS Global Real Estate Bubble Index, in which other “bubble risk” cities include Stockholm, Munich, Sydney, London, Hong Kong and Amsterdam.The Swiss-based global financial services company said that the bubble risk in all of these cities has spiked over the last five years as house prices have climbed by almost 50 per cent on average since 2011.However, “bubble risk seems greatest in Toronto, where it has increased significantly in the last year,” it noted.Notably, prices rose more than 10% in the last year alone in Toronto, Munich, Amsterdam, Sydney and Hong Kong.“Annual price-increase rates of 10% correspond to a doubling of house prices every seven years, which is not sustainable,” the UBS report said.“Nevertheless, the fear of missing out on further appreciation predominates among home buyers.”The report is based on data up to the second quarter of 2017.In Canada a large part of the negative impact of higher purchase prices on affordability has been cushioned by low mortgage rates.An overly loose monetary policy for too long, in addition to buoyant foreign demand which governments in B.C. and Ontario have tried to cool with the introduction of 15 a per cent foreign buyers tax, have also played a role in unmooring housing markets from economic fundamentals in Canada, UBS said.British Columbia was the first province to introduce a foreign buyer’s tax in August of 2016, which resulted in a 19 per cent plunge in sales and 16.7 per cent fall in prices compared to the previous month.Ontario followed suit in April, bringing in more than a dozen measures, including a 15 per cent tax on foreign buyers. The number of homes sold the following month fell 37.3 per cent from a year earlier and average home prices fell 13.8 per cent.As Toronto and Vancouver’s accelerating house prices have moved in rough lockstep over the last decade, neither city was dragged down by the financial crisis or weakening commodity prices due to the buffering effect of a depreciated Canadian dollar.But UBS said a strengthening loonie and further interest rate hikes would “end the party” for Toronto.Its report said that price growth accelerated last year in Toronto and reached an excessive 20 per cent year on year in the second quarter, whereas it peaked in Vancouver in the middle of last year when real estate prices soared 25% year on year before slowing to per cent in the latest quarter.The Bank of Canada raised rates twice over the summer following the economy’s surprisingly powerful start to the year.However, governor Stephen Poloz said during a speech Wednesday that he has no prearranged route for further interest-rate hikes, insisting that the central bank would be taking a more cautious approach to any future increases.Follow @DaveHTO on Twitter.
A London Olympics that started with a whimper for Michael Phelps has been a big bang ever since, including Thursday, when he increased his most medals record to 20 by besting American rival Ryan Lochte in the 200-meter individual medley.Lochte said these Games were “my time” after he opened by winning the gold medal in the 400 individual medley. He also said Phelps, who finished fourth in that event, would come back more determined than ever.Lochte was wrong about the first, right about the second.Phelps earned his 16th gold medal by handled the field in a time of 1 minute, 54.27 seconds, just off his winning time in Beijing. The silver went to Lochte and Hungary’s Laszlo Cseh took the bronze.So his final Olympics that looked bleak at the start look golden now. He was not as dominant as he was four years ago in Beijing. But his medal count this year rests at two golds and two silvers in five races – and he still has two more events to go.In fact, as soon as Phelps finished off Lochte, he hopped out of the pool and headed to the nearby diving well to warm down, knowing he still had a semifinal of the 100 butterfly before the night was done.Lochte had gone through the same routine just a few minutes earlier, trying to pull off an impressive double 31 minutes apart. He came up short in both races, fading to bronze in the 200 backstroke behind fellow American Tyler Clary, then touching after Phelps in the medley.Phelps’ reaction wasn’t a water-pounding celebration, just look of relief. He seemed to be soaking it all in, relishing a gold of his own in London with his previous victory coming in the 4×200 freestyle relay.Lochte shook hands with his rival before crawling out of the pool for the last time at these Games. In a symbolic gesture, he tossed his cap and goggles into the crowd, his work done. His final tally: two golds, two silvers, one bronze and a fourth-place finish — impressive, but undoubtedly shy of what he had predicted would be “my time.”
OSU junior guard Kelsey Mitchell dribbles past senior guard Christen Inman of Northwestern. OSU won, 99-68 in the third round of the Big Ten tournament at Bankers Life Fieldhouse in Indianapolis on March 3. Credit: Ashley Nelson | Sports DirectorOn Wednesday night Ohio State junior guard Kelsey Mitchell announced she will return for her senior season with the Buckeyes. Mitchell is the all-time leader in three-point made field goals and is just 265 points away from leading the Buckeyes in all-time points scored.Mitchell released a statement giving her reasons to return, citing her studies and getting the Buckeyes to the Final Four.“Getting a degree from The Ohio State University was one of my top goals when coming to college and I look forward to completing my degree next spring. My teammates and I also have a number of goals we have yet to accomplish on the court. One of those goals is to play in the Final Four and we have a tremendous opportunity to do that next year here in Columbus. I’m excited to get back in the gym with my teammates and continue to work to get better,” she said.Earlier this week she was named an Associated Press All-American, her third time earning the title in her three seasons of play. Mitchell was also named this year’s Big Ten Player of the Year for the second time.
Litter louts can face on-the-spot fines of €150 or court fines of €3,000. Morto.Anyone who is convicted of a litter offence might also be asked to pay costs.If you own a premises to which the public has access then it’s your responsibility to keep it litter free e.g. a shopping centre, school, park, bus station.It’s your responsibility to keep your private property free from litter if it can be seen from a public place.The council can ask somebody how they’re getting rid of their waste if they’re not availing of a refuse collection service.Clean up after your dog! Please! (We added the please)H/T to RedditPoll: Have you ever personally complained to someone about littering?Dublin council removes 48 street bins to deter illegal dumping> BEWARE THOSE WHO dare to litter on South Dublin County Council’s watch.A giant bin might appear out of the bushes to attack you for your disgusting ways.In addition to a ferocious attack from a stealthy bin, you can also expect a hefty fine if you’re caught littering. Here are some tips from SDCC’s ‘Litter and the Law‘:
M-Disc : un DVD presque indestructible, qui résiste au tempsLa start-up américaine Millenniata travaille en collaboration avec LG sur un nouveau type de disque optique. Baptisé M-Disc, ce support est censé résister aux épreuves du temps, pendant au moins mille ans.Créée en 2007 aux Etats-Unis, la start-up Millenniata lancera très prochainement un nouveau type de DVD, presque indestructible, affirme-t-elle sur son site Internet (lien non disponible). Baptisé M-Disc, il est en effet censé durer très longtemps, au moins mille ans, quand les DVD classiques peuvent rapidement devenir illisibles. Alors qu’il est compatible avec n’importe quel lecteur DVD, et offre la même capacité qu’un simple couche, soit 4,7 Go, le M-Disc a été conçu pour résister aux agressions extérieures comme l’eau, le feu, et même l’azote liquide.À lire aussiLG : l’Optimus 4X HD arrive en juin Autant dire que cette nouvelle technologie suscite de nombreuses interrogations. Mais Millenniata ne dévoile pas quel matériau a été utilisé pour créer ce DVD, se contentant d’évoquer une matière naturelle, qui présente un aspect minéral. La start-up explique en revanche que le M-Disc est dénué de couche organique, contrairement aux disques optiques actuels. C’est un des facteurs qui le rend si robuste.Des graveurs spécifiques Millenniata précise toutefois que, s’il sera compatible avec les actuels lecteurs de DVD, le M-Disc, qui n’est pas réinscriptible, nécessitera un nouvel appareil pour l’écriture. En partenariat avec la start-up, LG lancera dès le mois d’octobre un lecteur-graveur destiné aux M-Disc qui seront eux aussi vendus à l’automne, pour 3 dollars l’unité. Mais la société promet que les fabricants de lecteurs DVD pourront produire des appareils compatibles via une simple mise à jour du firmware de leurs lecteurs actuels. Le 14 août 2011 à 13:25 • Maxime Lambert
If you go to the grocery store often, you’re probably no stranger to employees offering samples of food and drink dotting the supermarket, especially if you to go places like Costco or Sam’s Club. They’re everywhere, and they’re awesome. Sometimes you can get two samples if you ask nicely. This Asahi beer salesperson isn’t human, but she can totally sell you on some beer or something. Probably.This isn’t a new thing in Japan. These CG salespeople are pretty hot there, as they serve up free samples and try to chat you up about the product they’re selling. There’s a video you can check out that kind of explains the process, but it doesn’t get much more simple than “Hey, this robot lady can help you figure out what kind of beer you want from Asahi.:The signs themselves are known as “virtual mannequins” and have apparently been around for the last seven years or longer, offering their services, so humans don’t have to do the work they’re asked to do, sitting around and talking about Asahi beer all day or what-have-you. You can see them in action from folks who have walked by them in the store, and they honestly look pretty cool.裏はこうなってた pic.twitter.com/BCWmpZXIMs— りゅうせい㌠ 土曜日 C-22b (@dotno_hamutarou) July 27, 2017 It would make sense to have something like this here in America, especially since we do have so many products on offer at any given time in supermarkets that offer that kind of convenience. But you’d also need someone to shepherd people from taking every single sample at the display because people are heathens when free food is involved, and that, like the Muses from Hercules say, is the gospel truth.These signs are pretty amazing when you think about it, though. Would you be freaked out if you happened upon one while hanging out at your local market?Let us know what you like about Geek by taking our survey. Launchpad Blaze Postpones JAXA’s Cargo Ship Launch to ISSJapan’s Hayabusa-2 Probe Packs Up Space Rock Cargo From Asteroid Ryugu Stay on target
The Brazilian winger scored twice to help West Ham United win 4-2 against Burnley in the English Premier League 2018-2019 seasonBrazilian winger Felipe Anderson scored twice for West Ham United in the 4-2 win over Burnley yesterday in the English Premier League.And the footballer couldn’t be happier after the work done by him and his team.“I’m very happy. We were really looking for that victory. We were really working for it,” he told the club’s official website.“I hoped it happened, whether I scored or not, but I’m happy I contributed with goals and a good performance and I’m very happy for this home victory by two goals.”Jose Mourinho is sold on Lampard succeeding at Chelsea Tomás Pavel Ibarra Meda – September 14, 2019 Jose Mourinho wanted to give his two cents on Frank Lampard’s odds as the new Chelsea FC manager, he thinks he will succeed.There really…“I’m always looking to help the team, with a goal, a move, a pass or any way I can but if I do it with a goal or an assist I’m even happier,” he added.“It was a great day, we played really well regardless of how hard the match was, we were up to the challenge and we got the result we were looking for.”“At 1-1 we believed we could win it, I scored and they equalized again and for some seconds we couldn’t believe it but we are a team that fights until the very end, that believe in themselves and that helped us stay in the game,” he commented.“It’s better to work with a win, we have serenity, confidence and we want to get more.”
SEATTLE — For immigrants living in the country illegally, the new health care coverage under President Barack Obama’s Affordable Care Act will be simple: They don’t get any. In Washington state, however, some of those immigrants can still qualify for certain already-existing state health programs.Both immigrants legally in the country and those illegally here who qualify for state programs will be able to look up their eligibility through the web portal created by the Washington Health Benefit Exchange.Those are a few nuggets of information in often-confusing health care facts the exchange is tasked with diffusing among minority populations in the state before enrollment begins on Oct. 1 for the expanded marketplace of health insurances.“We have to make sure 6.5 million people are aware of what’s happening,” said Michael Marchand, communications director for the exchange.According to U.S. Census figures, nearly half a million Washington residents over age 5 speak a language other than English and say they don’t speak English very well. More than 200,000 say Spanish is their primary language, but another 150,000 say they speak an Asian or Pacific Islander language.In all, people in Washington who don’t speak English well speak more than 150 different languages, not including dialects, according to the Census.State officials estimate about 1 million Washington residents are uninsured, or about one in seven people who live in the state. About a third of them will likely become eligible for free health insurance under the expanded Medicaid. The rest will be targeted by the state’s new health insurance exchange.
Northbound and southbound traffic should be aware of the detour onto Kalifornsky Beach Road. DOT has begun the process of widening the shoulders of the Sterling Highway from MP 97 to 118. Crews will be working to widen the highway shoulders and install four large diameter culverts. Construction crews will be working between MP 105 and 107 to replace the Coal Creek Culvert. Shannon McCarthy with the Department of Transportation: “We are doing this to replace the culvert at Coal Creek, this does take both widths of the highway. This means people will have to detour down K-Beach Road.” Facebook0TwitterEmailPrintFriendly分享Beginning at 8:00pm on Friday, April 5 through Friday, April 12, the Sterling Highway will be closed at MP 106, south of Soldotna. This project is scheduled to be completed by October 2019. Construction work includes pavement removal, unclassified excavation, embankment, grading, paving, stream diversions, stream channel construction, stream bank construction, culvert installation, signing, and striping.
Terms of the deal weren’t disclosed, nor was a specific timeline for launching the apps, though Lewis D’Vorkin, chief product officer for Forbes, says they’re well into the development process already. He expects the company will have multiple new apps in the market by the end of this year. Specifically, Forbes will look to leverage the private sharing, notification and profile aspects of Camerama’s tech, as opposed to its photo capabilities. The company’s founder, Salah Akram Zalatimo, will also join Forbes as vice president of mobile products. D’Vorkin says it’s yet to be determined if the products will be free or paid, but monetization will stay close to the models Forbes uses already. While the publisher already has a handful of apps to its name—they range from standard magazine access points to more personalized utilities on topics like financial planning—they’re all essentially distribution mechanisms for Forbes editorial content. The new apps will have Forbes content on them, D’Vorkin says, but that won’t be the focus. “We’re moving forward on creating a series of apps that are much more about niche communities, very social network-esque, and aren’t just a distribution platform for [Forbes] content,” D’Vorkin says. “The bulk [of the content] will come from communities sharing, posting, working with each other within the app.” “These apps will be about streams and streaming content, so our [native advertising platform] Brandvoice and our sponsorships will be the most suitable for this,” he says. “These apps are a wonderful way for us to appeal to smaller, niche audiences. It’s an area of the marketplace that advertisers want to reach. They want the right group of people in a very curated environment. So we’ll be able to accomplish two of our goals with our targeted apps and the scale of the website.” Forbes Media bought photo-sharing app, Camerama, Monday as part of a larger effort to establish several niche app environments for its community. App development is the latest tech venture Forbes has taken in recent years. The company has invested heavily in its own site and, notably, its contributor network CMS, Forbes Falcon, which was licensed to B2B publisher ALM in 2013.
The Alaska Marine Highway System announced more changes to the Alaska Class Ferry rollout this week, but the summer schedule is still uncertain.The Alaska Marine Highway System changed its plans for Alaska Class Ferries in the Upper Lynn Canal again. AMHS Public Information Officer Aurah Landau says the new plan will get Alaska Class Ferries in service sooner and save money.“The Tazlina will be the first of the Alaska Class Ferries available and we can move right into Lynn Canal for the summer schedule,” Landau said.The ACF Tazlina is finished and has completed sea trials. It will service the Upper Lynn Canal starting in May of this year. This is an update from the October 2018 plan, which had the Hubbard scheduled to run between Juneau, Haines and Skagway, and the Tazlina providing service in Prince William Sound out of Cordova. Landau says the Hubbard will be complete by late spring or early summer.AMHS does not have a summer schedule yet.“Service schedule for the summer is still being adjusted and it will change timing and routing for some of the other vessels–those mainline routes that come up from Bellingham and Prince Rupert,” said Landau.The Tazlina will replace the Fairweather. The ACF Hubbard will replace the Aurora in Prince William Sound sometime in 2020. AMHS says retiring the Fairweather and Aurora will save millions. AMHS does not have an exact date for their retirements. The Fairweather is currently in “layup” for the winter and will not undergo a million dollar maintenance overhaul.AMHS asked for $27 million in capital funds to add crew cabins to the ACFs last year. Crew cabins would allow staff to stay on board for longer periods without overtime pay. The switch means the Tazlina and the Hubbard will go into service without crew quarters.“Yeah the Tazlina will be operating as a day boat in the Lynn Canal,” said Landau. “The operational details are still being worked out for that. We’re looking at where those crews might be overnighted, where it makes sense to have service, and how we can maintain a strong high level of service for Lynn Canal communities while using the day boats.”AMHS does plan to add forward side doors to both vessels which will cost about $3 million.Service to the Upper Lynn Canal will stay roughly the same. AMHS says the Tazlina is slower than the Fairweather and is likely to run 7 days a week. The Tazlina holds more passengers and vehicles than the Forweather and is more fuel efficient. AMHS anticipates saving half a million dollars in fuel annually.AMHS will contact any any passengers affected by schedule changes to rebook or refund.
Karan OberoiInstagramTelevision actor and singer Karan Oberoi, who was accused of rape and blackmail by a female friend, has been granted bail on Friday, June 7 by the Bombay High Court. The high-profile case has had many twists and turns, giving rise to the debate on the #MenToo movement as far as sexual harassment is concerned.Karan Oberoi had been arrested for the alleged rape and blackmail of a female astrologer in Mumbai on May 6 and sent to 14 days’ judicial custody. In a very filmy twist to the tale, the complainant was attacked and it turned out that the goons attacking her were sent by her own lawyer, Ali Kashif Khan. On June 3, Khan surrendered before Oshiwara police. He was arrested and later granted bail by the Andheri court.Karan Oberoi’s friend and actress Pooja Bedi was the first to come out in support of him, saying he has been victimised by a woman who was in love with him. Karan’s sister Gurbani aka Vani, and his band members from Band of Boys, Sudhanshu Pandey, Chintoo Bhosle and Sherrin Verghese also spoke for him at a press conference soon after his arrest.Reports said the complainant had met the accused via a dating application in 2016, after which he promised to marry her. A report in Mumbai Mirror, without naming the actor, had said that the Oshiwara police had registered a first information report (FIR) against the actor-singer for allegedly raping an astrologer under the pretext of marrying her. The victim has also alleged that he had recorded a video on his mobile phone. This happened after he allegedly sedated her with spiked coconut water in his flat. He later allegedly extorted money from her.Much of this has turned out to be a conspiracy after the accused submitted WhatsApp chats with the complainant, clearly showing her one-sided interest in him and that he had never promised to marry her. Vani also confirmed that Karan and the complainant were never intimate.Karan Oberoi acted in the recent web series Inside Edge. He was also seen in the popular TV series like Jassi Jaissi Koi Nahin and Saaya, apart from singing with Band of Boys.
Listen 00:00 /01:45 Share X To embed this piece of audio in your site, please use this code: Laura IsenseeThe Karachi airport in Pakistan.At the Karachi airport and ready to board back West, Laura Isensee reflects on her visit to Pakistan as a journalist.Pakistan is seen as very black and white, Laura says, but it’s all about the grey in between extremism and progress. There is also a collective effort to create positive change, which leaves her feeling optimistic for the country.And check out Laura’s earlier entries on the special page on our website.
For the fragments that contain stable hydrophobic contacts (which cause the protein to fold), the protein/computer enforces these contacts and adds more residues to enlarge these points. If new hydrophobic contacts are formed again, the process continues until no more contacts are found.“The protein doesn’t ‘know’ it has the right starting points at the early stages,” Dill explained. “It explores many possible avenues. But, we find that when the chain pieces have reached roughly the 16-to-24-mer stage, then the differences in free energy begin to become compelling, and structures begin to emerge fairly clearly.”In some cases, this zipping procedure alone is enough for a protein to reach its native form. For other cases, the ZA algorithm switches to the assembly procedure, combining two or more fragments to form additional structures until the native form is achieved. The ZA method was tested on nine small proteins, eight of which closely matched the experimental results of samples in the Protein Data Bank. The greatest sign that the ZA method is on the right track is its speed. For example, using ZA, protein G could fold in about 1 CPU year on a 2.8-Ghz Xeon Intel machine.“We don’t know exactly what the speed gain is,” Dill said. “Our largest protein studied is a 112-mer (subsequent to the PNAS paper). Currently the most extensive all-atom physical simulations on Folding@Home, with 100,000 processors, or IBM’s Blue Gene, built for this problem, are on smaller proteins, typically in the range of 20-40 amino acids long. However, those simulations are also more directed at physical questions of folding, rather than at protein structure prediction, so it’s hard to make a direct comparison.”Citation: Ozkan, S. Banu, Wu, G. Albert, Chodera, John D., and Dill, Ken A. “Protein folding by zipping and assembly.” Proceedings of the National Academy of Sciences, July 17, 2007, vol. 104, no. 29, 11987-11992.Copyright 2007 PhysOrg.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of PhysOrg.com. Citation: Divide-and-conquer strategy key to fast protein folding (2007, August 6) retrieved 18 August 2019 from https://phys.org/news/2007-08-divide-and-conquer-strategy-key-fast-protein.html Researchers have found that proteins may use a divide-and-conquer strategy to fold into their native states in mere microseconds. The physical strategy, called “zipping and assembly” (ZA), can increase the speed at which supercomputers predict protein folding structures, greatly increasing scientists’ understanding of these building blocks of life. Explore further Ribbon diagrams of nine protein structures: Protein Data Bank structures are in orange, while Zipping & Assembly structures are in blue. Credit: Ozkan, et al. ©2007 PNAS. The scientists, Banu Ozkan, Albert Wu, John Chodera, and Ken Dill from the University of California at San Francisco, have published their research in a recent issue of the Proceedings of the National Academy of Sciences. Their results show that the ZA search strategy provides a physics-based model of protein folding that could lead to advances such as computer-based drug discovery and genetic engineering.“Our research has two significant points, I believe,” Dill told PhysOrg.com. “First, it shows that all-atom physical force fields are pretty good (but not perfect), and may be useful for protein structure prediction. And second, it proves that zipping and assembly is a highly efficient conformational search method, and supports the view that ZA may be the physical mechanism of protein folding.”Proteins, which consist of an unstructured linear chain of amino acids, can fold into complex 3D structures within microseconds. On the other hand, high-speed supercomputers might take tens of years to compute the correct structure due to the vast assortment of possible forms the protein could take. When folded incorrectly, proteins can cause neurodegenerative diseases such as Alzheimer’s and mad cow disease. How proteins fold so quickly is a mystery that researchers are approaching from many different angles, including, for example, physics-based force fields. By assigning force fields to different parts of the protein, computers can track the movement of each individual part.Using the ZA strategy, Ozkan, Wu, Chodera and Dill have sped up the rate at which computers using force fields can predict protein structures. In the ZA model, the first step that proteins (or computers) take is breaking the amino acid chain into 8-12 fragments to search for a very small fraction of favorable folding points (traditional methods usually search the entire chain).“The speed gain in our method comes from not exploring all possible folding routes, but instead from following only those routes that entail small conformational search steps,” Dill explained. “This reduces the search problem, in principle, from one that grows exponentially with the chain length to one that, instead, grows only as the first or second power of the chain length. While we haven’t actually proven that quantitatively, it is clear that the method is much faster than brute force Monte Carlo or molecular dynamics.” Parsley and dill help fight cancer, research shows This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Streaming giant Netflix recently unveiled their new slate of Original series with superstar Shah Rukh Khan and Anushka Sharma attached as producers on two different projects. According to Netflix, Shah Rukh’s Red Chillies Entertainment will produce zombie horror ‘Betaal’, while Anushka and Karnesh Sharma’s Clean Slate Films will serve as executive producers on ‘Mai’. “This is my second collaboration with Netflix after ‘Bulbul’ and we are again looking to disrupt the kind of content audiences are consuming. We at Clean Slate Films have been dedicated to making clutter-breaking, powerful stories since our first production and we are looking forward to push the content envelope,” Anushka said in a statement. Also Read – Add new books to your shelf”The creative freedom to be able to translate these stories to screens that reach a global audience is exciting for us, which is why Netflix is such an important partner.” ‘Mai’ revolves around 47-year-old wife-and-mother, Sheel, who finds herself accidentally sucked into a rabbit hole of violence and power, following a personal tragedy. The series is penned by Atul Mongia along with Tamal Sen, Amita Vyas, with Sudip Sharma as a creative producer. Also Read – Over 2 hours screen time daily will make your kids impulsiveShah Rukh’s ‘Betaal’, which also marks the actor’s second collaboration with Netflix, is based in a remote village, visited by two-century-old Betaal, a British Indian Army officer, and his battalion of zombie. “With Indian police pitted against the undead army, hapless villagers are trapped in a horrific, edge-of-your-seat conflict,” the plot line read. Patrick Graham is attached as writer/director and showrunner, along with Nikhil Mahajan as the director and Suhani Kanwar as writer. The Original will be executive produced by Blumhouse, known to design some of the best horror content, and Ivanhoe. Apart from this, Netflix is coming with ‘Masaba Masaba’, a scripted series based on real-life moments from fashion designer Masaba Gupta’s life. The series will star Masaba along side her mother, veteran actor Neena Gupta, as themselves. The genre-bending show is created and produced by Ashvini Yardi’s Viniyard Films and will be directed by Sonam Nair. Alankrita Shrivastava’s Bombay Begums and American actor and director, Ravi Patel’s Messy, are also part of the streaming platform’s list of upcoming series. Bela Bajaria, VP, International Originals, Netflix, said they are excited to present these entertaining India-based stories. “India is home to some of the world’s greatest stories. It’s been thrilling to watch these amazing storytellers embrace the artistic freedom possible at Netflix to create entertaining stories. Audiences everywhere will love these five inventive series set in stories of horror, drama and comedy,” Bajaria said. Bombay Begums revolves around five women from different generations and their lives in contemporary urban India. Created, written and directed by Alankrita, the show has Chernin Entertainment and Endemolshine India attached as executive producers. Messy focuses on Mumbai’s rising stand-up comic, Beanie, who struggles to balance a career in comedy with pleasing a yuppie day-job boss, peculiar best friends forever, persistent parents, and proposal-popping boyfriend. Patel has co-written the series with Neel Shah.
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